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People who stop taking weight-loss medications gain back weight, studies show

Researchers says their research found some patients stop using the medication due to side effects, cost or because they are not comfortable with the injections.

Gillian Neff and Rose Shannon

May 17, 2025, 5:44 PM

Updated 3 hr ago

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Research from Stamford Health has found that people who stop using GLP-1 weight-loss medications ended up gaining the weight they lost back.
Researchers, in partnership with Sacred Heart University physician assistant students, analyzed hundreds of clinical studies to see what happens when patients stop using those medications.
"We included 2,372 participants. The patients taking liraglutide – they're gaining 25 to 30 percent of their weight back. For the combination of semaglutide and terzepitide, they regained 52 to 63 percent that they had originally lost," said researcher Suzanne Rose, MS, Ph.D. executive director of research at Stamford Health.
Rose says the weight gain happens within a few months after people stopping taking these drugs. She says the research found some patients stop using the medication due to side effects, cost or because they are not comfortable with the injections.
Rose tells News 12 her goal is to work with patients so they can achieve long-term success with their health and weight.
"Are they following diet and are they following fitness. And if they can't afford them, what are options here to help support our patients," she says.
She adds that while weight-loss medications have been shown to be safe and effective, it will take research and time to determine if they remain a strong option for treating obesity long-term.